Compound Detail
CHEMBL539935
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Basic Information
| ChEMBL ID | CHEMBL539935 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IZMMNYOCEHWHMF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
3.13
ALogP
2
HBA
1
HBD
31.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 4.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 3 CHEMBL3780 | Kd | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 3 | Kd | = | 14000.0 | nM | 4.85 | Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by wh... | 18998663 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18998663 | 10.1021/jm800809f | Small conductance calcium-activated potassium channel protein 3 | 1 |
Data from ChEMBL 36 via Core Engine