Assay Detail
Binding
CHEMBL1008237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr
80
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 80 | 5.00 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376503 | — | — | 2 | 7.05 |
| CHEMBL1157 | ADIPIC ACID | -1.0 | 2 | 6.39 |
| CHEMBL1057 | FLUORESCEIN | 4.0 | 2 | 5.53 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 2 | 5.47 |
| CHEMBL521 | IBUPROFEN | 4.0 | 2 | 5.33 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | — | 2 | 5.21 |
| CHEMBL897 | PROBENECID | 4.0 | 2 | 5.20 |
| CHEMBL1162495 | GLUTARATE | — | 2 | 5.17 |
| CHEMBL463 | AMINOHIPPURIC ACID | 4.0 | 2 | 5.03 |
| CHEMBL320358 | HEPTANOATE | — | 2 | 4.78 |
| CHEMBL1162491 | OCTANEDIOATE | — | 2 | 4.47 |
| CHEMBL14184 | HEXANOATE | — | 2 | 4.43 |
| CHEMBL1162487 | — | — | 1 | 4.25 |
| CHEMBL1162486 | — | — | 1 | 4.25 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | — | 2 | 4.25 |
| CHEMBL461 | HIPPURIC ACID | — | 2 | 4.25 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | — | 2 | 4.14 |
| CHEMBL1162488 | PHENYLPYRUVATE | — | 2 | 4.10 |
| CHEMBL1162144 | PYRUVATE | 2.0 | 2 | - |
| CHEMBL1162479 | — | — | 2 | - |
| CHEMBL14227 | BUTYRIC ACID | 2.0 | 2 | - |
| CHEMBL568737 | 3-METHYLBUTANOIC ACID | — | 2 | - |
| CHEMBL1162481 | DEAMINOHYDROXYVALINE | — | 1 | - |
| CHEMBL1162480 | — | — | 1 | - |
| CHEMBL1162483 | — | — | 1 | - |
| CHEMBL1162482 | — | — | 1 | - |
| CHEMBL1162484 | (R)-3-HYDROXYBUTANOATE | — | 1 | - |
| CHEMBL1162497 | — | — | 1 | - |
| CHEMBL1162490 | — | — | 1 | - |
| CHEMBL1162494 | N-ACETYLASPARTIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376503 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL376503 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL1157 | ADIPIC ACID | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL1157 | ADIPIC ACID | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL1057 | FLUORESCEIN | Ki | = | 2951.21 | nM | 5.53 |
| CHEMBL1057 | FLUORESCEIN | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 3388.44 | nM | 5.47 |
| CHEMBL521 | IBUPROFEN | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL521 | IBUPROFEN | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL897 | PROBENECID | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL897 | PROBENECID | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL1162495 | GLUTARATE | Ki | = | 6760.83 | nM | 5.17 |
| CHEMBL1162495 | GLUTARATE | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL463 | AMINOHIPPURIC ACID | Ki | = | 9332.54 | nM | 5.03 |
| CHEMBL463 | AMINOHIPPURIC ACID | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL320358 | HEPTANOATE | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL320358 | HEPTANOATE | Ki | = | 16595.87 | nM | 4.78 |
| CHEMBL1162491 | OCTANEDIOATE | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL1162491 | OCTANEDIOATE | Ki | = | 34100.0 | nM | 4.47 |
| CHEMBL14184 | HEXANOATE | Ki | = | 37153.52 | nM | 4.43 |
| CHEMBL14184 | HEXANOATE | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL1162486 | — | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL461 | HIPPURIC ACID | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL1162487 | — | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL461 | HIPPURIC ACID | Ki | = | 55600.0 | nM | 4.25 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | Ki | = | 72443.6 | nM | 4.14 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL1162488 | PHENYLPYRUVATE | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL1162488 | PHENYLPYRUVATE | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL1162484 | (R)-3-HYDROXYBUTANOATE | Ki | = | 3235936.57 | nM | - |
| CHEMBL1162482 | — | Ki | = | 912010.84 | nM | - |
| CHEMBL1162483 | — | Ki | = | 912010.84 | nM | - |
| CHEMBL1162479 | — | Ki | = | 14200000.0 | nM | - |
| CHEMBL1162480 | — | Ki | = | 14125375.45 | nM | - |
| CHEMBL1162481 | DEAMINOHYDROXYVALINE | Ki | = | 14125375.45 | nM | - |
| CHEMBL1162479 | — | Ki | = | 14125375.45 | nM | - |
| CHEMBL1160012 | — | Ki | = | 912010.84 | nM | - |
| CHEMBL14021 | PROPIONIC ACID | Ki | = | 8128305.16 | nM | - |
| CHEMBL1162144 | PYRUVATE | Ki | = | 11900000.0 | nM | - |
| CHEMBL503160 | FUMARIC ACID | Ki | = | 616595.0 | nM | - |
| CHEMBL1160012 | — | Ki | = | 920000.0 | nM | - |
| CHEMBL1162144 | PYRUVATE | Ki | = | 12022644.35 | nM | - |
| CHEMBL14021 | PROPIONIC ACID | Ki | = | 8180000.0 | nM | - |
| CHEMBL14227 | BUTYRIC ACID | Ki | = | 3467368.5 | nM | - |
| CHEMBL14227 | BUTYRIC ACID | Ki | = | 3500000.0 | nM | - |