Assay Detail
Binding
CHEMBL1008329
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Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LMtk- |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.67 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524085 | — | — | 1 | 9.16 |
| CHEMBL526084 | — | — | 1 | 9.08 |
| CHEMBL495580 | — | — | 1 | 9.08 |
| CHEMBL497641 | — | — | 1 | 9.07 |
| CHEMBL521545 | — | — | 1 | 9.04 |
| CHEMBL521537 | — | — | 1 | 9.00 |
| CHEMBL497621 | — | — | 1 | 9.00 |
| CHEMBL496196 | — | — | 1 | 8.96 |
| CHEMBL523060 | — | — | 1 | 8.96 |
| CHEMBL495630 | — | — | 1 | 8.96 |
| CHEMBL496621 | — | — | 1 | 8.92 |
| CHEMBL526645 | — | — | 1 | 8.89 |
| CHEMBL522388 | — | — | 1 | 8.85 |
| CHEMBL496392 | — | — | 1 | 8.77 |
| CHEMBL496399 | — | — | 1 | 8.74 |
| CHEMBL495625 | — | — | 1 | 8.74 |
| CHEMBL497211 | — | — | 1 | 8.72 |
| CHEMBL525173 | — | — | 1 | 8.66 |
| CHEMBL495594 | — | — | 1 | 8.64 |
| CHEMBL491930 | — | — | 1 | 8.62 |
| CHEMBL523228 | — | — | 1 | 8.62 |
| CHEMBL495593 | — | — | 1 | 8.54 |
| CHEMBL522237 | — | — | 1 | 8.47 |
| CHEMBL522378 | — | — | 1 | 8.46 |
| CHEMBL482667 | — | — | 1 | 8.43 |
| CHEMBL496197 | — | — | 1 | 8.41 |
| CHEMBL496393 | — | — | 1 | 8.24 |
| CHEMBL497839 | — | — | 1 | 8.21 |
| CHEMBL521723 | — | — | 1 | 8.10 |
| CHEMBL495828 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524085 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL526084 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL495580 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL497641 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL521545 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL521537 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL497621 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL496196 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL523060 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL495630 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL496621 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL526645 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL522388 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL496392 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL495625 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL496399 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL497211 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL525173 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL495594 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL491930 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL523228 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL495593 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL522237 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL522378 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL482667 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL496197 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL496393 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL497839 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL521723 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL495828 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL497644 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL521124 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL522245 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL521556 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL495996 | — | IC50 | > | 1000.0 | nM | - |