Compound Detail
CHEMBL496393
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Basic Information
| ChEMBL ID | CHEMBL496393 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RMAMQNKLHRDEKZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
414.5
MW (Da)
3.77
ALogP
5
HBA
1
HBD
84.4
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 CHEMBL4561 | IC50 | 8.24 | 8.24 | 5.7 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | - | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 | IC50 | = | 5.7 | nM | 8.24 | Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mo... | 19464889 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19464889 | 10.1016/j.bmcl.2009.05.013 | Rattus norvegicus | 2 |
| 19464889 | 10.1016/j.bmcl.2009.05.013 | Cytochrome P450 3A4 | 2 |
| 19464889 | 10.1016/j.bmcl.2009.05.013 | Neuropeptide Y receptor type 5 | 1 |
| 19464889 | 10.1016/j.bmcl.2009.05.013 | Brain | 1 |
| 19464889 | 10.1016/j.bmcl.2009.05.013 | Cerebrospinal fluid | 1 |
Data from ChEMBL 36 via Core Engine