Assay Detail
Binding
CHEMBL1008805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from SERT in rat brain stem membrane
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.14 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.98 |
| CHEMBL498600 | — | — | 1 | 6.69 |
| CHEMBL497586 | — | — | 1 | 6.56 |
| CHEMBL496753 | — | — | 1 | 6.50 |
| CHEMBL495520 | — | — | 1 | 6.28 |
| CHEMBL502790 | — | — | 1 | 6.26 |
| CHEMBL489601 | — | — | 1 | 6.18 |
| CHEMBL495519 | — | — | 1 | 6.11 |
| CHEMBL314424 | — | — | 1 | 6.09 |
| CHEMBL495726 | — | — | 1 | 6.08 |
| CHEMBL490424 | — | — | 1 | 5.98 |
| CHEMBL505059 | — | — | 1 | 5.91 |
| CHEMBL443649 | — | — | 1 | 5.89 |
| CHEMBL487088 | — | — | 1 | 5.78 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 5.77 |
| CHEMBL507255 | — | — | 1 | 5.71 |
| CHEMBL444690 | — | — | 1 | 5.66 |
| CHEMBL521582 | — | — | 1 | - |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | - |
| CHEMBL560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL498600 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL497586 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL496753 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL495520 | — | Ki | = | 521.0 | nM | 6.28 |
| CHEMBL502790 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL489601 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL495519 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL314424 | — | Ki | = | 803.0 | nM | 6.09 |
| CHEMBL495726 | — | Ki | = | 835.0 | nM | 6.08 |
| CHEMBL490424 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL505059 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL443649 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL487088 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 1711.0 | nM | 5.77 |
| CHEMBL507255 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL444690 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL521582 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | - | — | - | |
| CHEMBL560 | — | Ki | - | — | - |