Assay Detail
Binding
CHEMBL1010500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL475582 | — | — | 1 | - |
| CHEMBL475583 | — | — | 1 | - |
| CHEMBL450206 | — | — | 1 | - |
| CHEMBL475350 | — | — | 1 | - |
| CHEMBL505877 | — | — | 1 | - |
| CHEMBL475423 | — | — | 1 | - |
| CHEMBL472417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL475582 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL475583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL450206 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL475350 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL505877 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL475423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL472417 | — | IC50 | > | 10000.0 | nM | - |