Assay Detail
Binding
CHEMBL1010734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 8.52 |
| Ki | 6 | 6.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513389 | ZENIDOLOL | 2.0 | 2 | 9.00 |
| CHEMBL509336 | RACTOPAMINE | 2.0 | 2 | 6.75 |
| CHEMBL462313 | — | — | 2 | 6.50 |
| CHEMBL714 | ALBUTEROL | 4.0 | 2 | 6.29 |
| CHEMBL2218907 | ZILPATEROL | 2.0 | 2 | 6.24 |
| CHEMBL49080 | CLENBUTEROL | 2.0 | 2 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513389 | ZENIDOLOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL513389 | ZENIDOLOL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL509336 | RACTOPAMINE | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL462313 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL509336 | RACTOPAMINE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL714 | ALBUTEROL | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL2218907 | ZILPATEROL | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL49080 | CLENBUTEROL | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL462313 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL714 | ALBUTEROL | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2218907 | ZILPATEROL | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL49080 | CLENBUTEROL | IC50 | = | 1300.0 | nM | 5.89 |