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Compound Detail

CHEMBL509336

RACTOPAMINE
🧪 Phase II
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🧪 Phase II
CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL509336
Name RACTOPAMINE
Phase Phase II
Structure Type MOL
InChI Key YJQZYXCXBBCEAQ-UHFFFAOYSA-N

Known Names

Ractopamina Ractopamine
2
Targets
3
Activities
3
Assay Types
1
PK Parameters
5
Publications
2
Known Names

Molecular Properties

301.4
MW (Da)
2.74
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic

Flags

Natural Product
USAN Stem -pamine
USAN Year 1987

Extended Properties

Molecular Formula C18H23NO3
MW 301.39
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.13

Activity Summary

EC50 1 meas. best 8.21
IC50 1 meas. best 6.48
Ki 1 meas. best 6.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL5414
EC50 8.21 8.21 6.2 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 6.75 6.75 180.0 1
Beta-2 adrenergic receptor
CHEMBL210
IC50 6.48 6.48 330.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 111.2 mL.min-1.g-1 Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19245211 10.1021/jm801211c Beta-2 adrenergic receptor 4
33606526 10.1021/acs.jmedchem.0c02047 POU domain, class 2, transcription factor 1 3
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
33606526 10.1021/acs.jmedchem.0c02047 Unchecked 1

Data from ChEMBL 36 via Core Engine