Assay Detail
Functional
CHEMBL1010737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as relaxation of carbachol-induced tissue contraction
12
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.51 | 8.21 |
| Emax | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509336 | RACTOPAMINE | 2.0 | 2 | 8.21 |
| CHEMBL2218907 | ZILPATEROL | 2.0 | 4 | 8.06 |
| CHEMBL714 | ALBUTEROL | 4.0 | 2 | 8.04 |
| CHEMBL49080 | CLENBUTEROL | 2.0 | 2 | 7.89 |
| CHEMBL462313 | — | — | 2 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509336 | RACTOPAMINE | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2218907 | ZILPATEROL | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL714 | ALBUTEROL | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL49080 | CLENBUTEROL | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2218907 | ZILPATEROL | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL462313 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL462313 | — | Emax | = | 105.0 | % | - |
| CHEMBL2218907 | ZILPATEROL | Emax | = | 102.0 | % | - |
| CHEMBL49080 | CLENBUTEROL | Emax | = | 100.0 | % | - |
| CHEMBL509336 | RACTOPAMINE | Emax | = | 105.0 | % | - |
| CHEMBL714 | ALBUTEROL | Emax | = | 100.0 | % | - |
| CHEMBL2218907 | ZILPATEROL | Emax | = | 103.0 | % | - |