Assay Detail
Binding
CHEMBL1011738
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Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.32 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.15 |
| CHEMBL446084 | — | — | 1 | 7.89 |
| CHEMBL454507 | — | — | 1 | 7.38 |
| CHEMBL465123 | SEPROXETINE | 2.0 | 1 | 7.34 |
| CHEMBL499461 | — | — | 1 | 6.76 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.38 |
| CHEMBL313041 | — | — | 1 | - |
| CHEMBL480988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL446084 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL454507 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL465123 | SEPROXETINE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL499461 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL370805 | COCAINE | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL313041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL480988 | — | IC50 | > | 100000.0 | nM | - |