Assay Detail
Functional
CHEMBL1012469
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Antiviral activity against HIV1 LAI in human MT2 cells assessed as inhibition of p24 antigen production by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.17 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472584 | — | — | 1 | 8.15 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.19 |
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472584 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL515564 | TENOFOVIR EXALIDEX | EC50 | < | 0.01 | nM | - |