Assay Detail
Binding
CHEMBL1013151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from rat cortical 5HTT reuptake site
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.69 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481113 | — | — | 1 | 8.96 |
| CHEMBL481754 | — | — | 1 | 8.89 |
| CHEMBL494276 | — | — | 1 | 8.80 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.57 |
| CHEMBL494484 | — | — | 1 | 8.48 |
| CHEMBL480932 | — | — | 1 | 8.46 |
| CHEMBL481747 | — | — | 1 | 8.34 |
| CHEMBL520753 | — | — | 1 | 8.31 |
| CHEMBL359495 | — | — | 1 | 8.28 |
| CHEMBL494483 | — | — | 1 | 8.07 |
| CHEMBL522529 | — | — | 1 | 7.94 |
| CHEMBL522671 | — | — | 1 | 7.90 |
| CHEMBL517996 | — | — | 1 | 7.89 |
| CHEMBL518946 | — | — | 1 | 7.87 |
| CHEMBL493684 | — | — | 1 | 7.87 |
| CHEMBL481108 | — | — | 1 | 7.86 |
| CHEMBL481914 | — | — | 1 | 7.70 |
| CHEMBL481940 | — | — | 1 | 7.57 |
| CHEMBL480935 | — | — | 1 | 7.42 |
| CHEMBL493037 | — | — | 1 | 7.42 |
| CHEMBL481753 | — | — | 1 | 7.41 |
| CHEMBL178267 | — | — | 1 | 7.31 |
| CHEMBL481112 | — | — | 1 | 7.24 |
| CHEMBL481523 | — | — | 1 | 7.21 |
| CHEMBL521110 | — | — | 1 | 7.20 |
| CHEMBL493455 | — | — | 1 | 7.17 |
| CHEMBL481109 | — | — | 1 | 7.14 |
| CHEMBL481337 | — | — | 1 | 7.12 |
| CHEMBL520265 | — | — | 1 | 7.12 |
| CHEMBL494688 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481113 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL481754 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL494276 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL494484 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL480932 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL481747 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL520753 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL359495 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL494483 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL522529 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL522671 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL517996 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL518946 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL493684 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL481108 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL481914 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL481940 | — | Ki | = | 26.7 | nM | 7.57 |
| CHEMBL493037 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL480935 | — | Ki | = | 38.5 | nM | 7.42 |
| CHEMBL481753 | — | Ki | = | 39.3 | nM | 7.41 |
| CHEMBL178267 | — | Ki | = | 48.5 | nM | 7.31 |
| CHEMBL481112 | — | Ki | = | 58.2 | nM | 7.24 |
| CHEMBL481523 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL521110 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL493455 | — | Ki | = | 67.5 | nM | 7.17 |
| CHEMBL481109 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL481337 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL520265 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL494688 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL481524 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL519616 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL494468 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL482266 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL31354 | WAY-100,635 | Ki | - | — | - |