Assay Detail
Binding
CHEMBL1013160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha MAPK expressed in Escherichia coli by radioisotopic protein kinase assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38alpha mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.83 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521424 | — | — | 1 | 7.56 |
| CHEMBL519294 | — | — | 1 | 7.55 |
| CHEMBL519620 | — | — | 1 | 7.51 |
| CHEMBL479987 | — | — | 1 | 7.31 |
| CHEMBL481354 | — | — | 1 | 7.26 |
| CHEMBL520437 | — | — | 1 | 7.26 |
| CHEMBL480945 | — | — | 1 | 7.25 |
| CHEMBL482301 | — | — | 1 | 7.20 |
| CHEMBL480787 | — | — | 1 | 7.20 |
| CHEMBL481761 | — | — | 1 | 7.11 |
| CHEMBL481339 | — | — | 1 | 7.06 |
| CHEMBL481752 | — | — | 1 | 7.02 |
| CHEMBL520949 | — | — | 1 | 7.00 |
| CHEMBL482300 | — | — | 1 | 6.85 |
| CHEMBL480940 | — | — | 1 | 6.83 |
| CHEMBL482129 | — | — | 1 | 6.72 |
| CHEMBL480944 | — | — | 1 | 6.65 |
| CHEMBL481338 | — | — | 1 | 6.58 |
| CHEMBL481347 | — | — | 1 | 6.46 |
| CHEMBL516760 | — | — | 1 | 6.08 |
| CHEMBL481513 | — | — | 1 | 6.07 |
| CHEMBL480933 | — | — | 1 | 6.04 |
| CHEMBL387748 | — | — | 1 | 5.99 |
| CHEMBL492634 | — | — | 1 | 5.37 |
| CHEMBL520919 | — | — | 1 | - |
| CHEMBL480936 | — | — | 1 | - |
| CHEMBL492858 | — | — | 1 | - |
| CHEMBL481757 | — | — | 1 | - |
| CHEMBL493686 | — | — | 1 | - |
| CHEMBL481917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521424 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL519294 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL519620 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL479987 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL481354 | — | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL520437 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL480945 | — | IC50 | = | 55.6 | nM | 7.25 |
| CHEMBL482301 | — | IC50 | = | 62.6 | nM | 7.20 |
| CHEMBL480787 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL481761 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL481339 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL481752 | — | IC50 | = | 95.4 | nM | 7.02 |
| CHEMBL520949 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL482300 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL480940 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL482129 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL480944 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL481338 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL481347 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL516760 | — | IC50 | = | 822.0 | nM | 6.08 |
| CHEMBL481513 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL480933 | — | IC50 | = | 916.0 | nM | 6.04 |
| CHEMBL387748 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL492634 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL493055 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL492849 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL495301 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL492848 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL522003 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL493685 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL481764 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL481917 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL493686 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL481757 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL492858 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL480936 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL520919 | — | IC50 | > | 1000.0 | nM | - |