Compound Detail
CHEMBL480944
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Basic Information
| ChEMBL ID | CHEMBL480944 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMMBXIRLZKDILC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
403.4
MW (Da)
3.30
ALogP
6
HBA
1
HBD
95.9
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 6.65 | 6.65 | 225.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 225.0 | nM | 6.65 | Inhibition of human recombinant p38alpha MAPK expressed in Escherichia coli by r... | 18571921 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18571921 | 10.1016/j.bmcl.2008.06.007 | TGF-beta receptor type-1 | 1 |
| 18571921 | 10.1016/j.bmcl.2008.06.007 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine