Assay Detail
Binding
CHEMBL1013550
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Displacement of [3H]paroxetine from 5HTT
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.10 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457865 | — | — | 1 | 9.02 |
| CHEMBL459333 | — | — | 1 | 9.00 |
| CHEMBL458488 | — | — | 1 | 8.77 |
| CHEMBL516933 | — | — | 1 | 8.70 |
| CHEMBL458282 | — | — | 1 | 8.54 |
| CHEMBL457866 | — | — | 1 | 8.54 |
| CHEMBL513090 | — | — | 1 | 8.51 |
| CHEMBL457415 | — | — | 1 | 8.46 |
| CHEMBL459332 | — | — | 1 | 8.46 |
| CHEMBL514424 | — | — | 1 | 8.39 |
| CHEMBL512202 | — | — | 1 | 8.37 |
| CHEMBL458072 | — | — | 1 | 8.32 |
| CHEMBL457655 | — | — | 1 | 8.26 |
| CHEMBL457416 | — | — | 1 | 8.12 |
| CHEMBL458080 | — | — | 1 | 8.08 |
| CHEMBL457635 | — | — | 1 | 7.54 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 7.02 |
| CHEMBL455937 | — | — | 1 | 7.00 |
| CHEMBL515988 | — | — | 1 | 6.87 |
| CHEMBL461241 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457865 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL459333 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL458488 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL516933 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL458282 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL457866 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL513090 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL457415 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL459332 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL514424 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL512202 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL458072 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL457655 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL457416 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL458080 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL457635 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL455937 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL515988 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL461241 | — | Ki | = | 860.0 | nM | 6.07 |