Assay Detail
Binding
CHEMBL1014663
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Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.66 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513103 | — | — | 1 | 9.09 |
| CHEMBL453520 | — | — | 1 | 8.78 |
| CHEMBL461444 | — | — | 1 | 8.56 |
| CHEMBL509403 | — | — | 1 | 8.44 |
| CHEMBL502147 | — | — | 1 | 8.39 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.34 |
| CHEMBL460590 | — | — | 1 | 8.28 |
| CHEMBL336920 | (R)-DULOXETINE | — | 1 | 8.06 |
| CHEMBL459519 | — | — | 1 | 8.02 |
| CHEMBL508252 | — | — | 1 | 7.92 |
| CHEMBL450173 | — | — | 1 | 7.52 |
| CHEMBL468914 | — | — | 1 | 7.50 |
| CHEMBL459732 | — | — | 1 | 7.40 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 7.32 |
| CHEMBL460372 | — | — | 1 | 7.30 |
| CHEMBL468915 | — | — | 1 | 7.14 |
| CHEMBL468916 | — | — | 1 | 7.07 |
| CHEMBL511690 | — | — | 1 | 6.78 |
| CHEMBL512120 | — | — | 1 | 6.57 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 6.56 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513103 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL453520 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL461444 | — | Ki | = | 2.72 | nM | 8.56 |
| CHEMBL509403 | — | Ki | = | 3.63 | nM | 8.44 |
| CHEMBL502147 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL1175 | DULOXETINE | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL460590 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL336920 | (R)-DULOXETINE | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL459519 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL508252 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL450173 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL468914 | — | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL459732 | — | Ki | = | 39.7 | nM | 7.40 |
| CHEMBL41 | FLUOXETINE | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL460372 | — | Ki | = | 49.9 | nM | 7.30 |
| CHEMBL468915 | — | Ki | = | 72.9 | nM | 7.14 |
| CHEMBL468916 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL511690 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL512120 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL295467 | NISOXETINE | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL641 | ATOMOXETINE | Ki | = | 1500.0 | nM | 5.82 |