Assay Detail
Binding
CHEMBL1015370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.50 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523299 | UMECLIDINIUM BROMIDE | 4.0 | 1 | 9.80 |
| CHEMBL524097 | — | — | 1 | 9.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523299 | UMECLIDINIUM BROMIDE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL524097 | — | Ki | = | 0.64 | nM | 9.19 |