Assay Detail
Functional
CHEMBL1015477
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Cytotoxicity against human DU145 cells after 72 hrs by trypan blue exclusion assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.56 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472250 | — | — | 1 | 5.98 |
| CHEMBL455735 | — | — | 1 | 5.95 |
| CHEMBL490446 | — | — | 1 | 5.91 |
| CHEMBL446811 | — | — | 1 | 5.84 |
| CHEMBL506834 | — | — | 1 | 5.73 |
| CHEMBL504040 | — | — | 1 | 5.71 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.67 |
| CHEMBL498908 | — | — | 1 | 5.53 |
| CHEMBL501640 | — | — | 1 | 5.48 |
| CHEMBL507617 | — | — | 1 | 5.25 |
| CHEMBL503113 | — | — | 1 | 5.24 |
| CHEMBL455342 | — | — | 1 | 5.23 |
| CHEMBL502430 | — | — | 1 | 5.16 |
| CHEMBL499994 | — | — | 1 | 5.09 |
| CHEMBL509089 | — | — | 1 | - |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | — | 1 | - |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472250 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL455735 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL490446 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL446811 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL506834 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL504040 | — | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL498908 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL501640 | — | EC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL507617 | — | EC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL503113 | — | EC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL455342 | — | EC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL502430 | — | EC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL499994 | — | EC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL509089 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | EC50 | > | 25000.0 | nM | - |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | EC50 | < | 25000.0 | nM | - |