Assay Detail
Binding
CHEMBL1015733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2c (CHEMBL2096911) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.74 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.00 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 4.64 |
| CHEMBL504772 | — | — | 1 | 4.27 |
| CHEMBL506027 | — | — | 1 | 4.04 |
| CHEMBL506409 | — | — | 1 | - |
| CHEMBL453769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL504772 | — | EC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL506027 | — | EC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL506409 | — | EC50 | = | 255000.0 | nM | - |
| CHEMBL453769 | — | EC50 | = | 429000.0 | nM | - |