Assay Detail
Binding
CHEMBL1017265
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Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.85 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487897 | — | — | 1 | 8.70 |
| CHEMBL504331 | — | — | 1 | 8.70 |
| CHEMBL472392 | — | — | 1 | 8.70 |
| CHEMBL487242 | — | — | 1 | 8.52 |
| CHEMBL458333 | — | — | 1 | 8.52 |
| CHEMBL502156 | — | — | 1 | 8.52 |
| CHEMBL450918 | — | — | 1 | 8.52 |
| CHEMBL487054 | — | — | 1 | 8.30 |
| CHEMBL487241 | — | — | 1 | 8.30 |
| CHEMBL487243 | — | — | 1 | 8.15 |
| CHEMBL461159 | — | — | 1 | 8.00 |
| CHEMBL488061 | — | — | 1 | 8.00 |
| CHEMBL462189 | — | — | 1 | 8.00 |
| CHEMBL459220 | — | — | 1 | 7.92 |
| CHEMBL487896 | — | — | 1 | 7.92 |
| CHEMBL514919 | — | — | 1 | 7.75 |
| CHEMBL459044 | — | — | 1 | 7.70 |
| CHEMBL521379 | — | — | 1 | 7.58 |
| CHEMBL461337 | — | — | 1 | 7.52 |
| CHEMBL520403 | — | — | 1 | 7.52 |
| CHEMBL488062 | — | — | 1 | 7.52 |
| CHEMBL521381 | — | — | 1 | 7.52 |
| CHEMBL487055 | — | — | 1 | 7.40 |
| CHEMBL462364 | — | — | 1 | 7.30 |
| CHEMBL518822 | — | — | 1 | 7.30 |
| CHEMBL519916 | — | — | 1 | 7.16 |
| CHEMBL462365 | — | — | 1 | 7.10 |
| CHEMBL461158 | — | — | 1 | 7.00 |
| CHEMBL516660 | — | — | 1 | 6.40 |
| CHEMBL487048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487897 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL504331 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL472392 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL487242 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL458333 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL502156 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL450918 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL487054 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL487241 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL487243 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL461159 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL488061 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL462189 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL459220 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL487896 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL514919 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL459044 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL521379 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL461337 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL520403 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL488062 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL521381 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL487055 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL462364 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL518822 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL519916 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL462365 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL461158 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL516660 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL487048 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL472393 | — | Ki | > | 4000.0 | nM | - |