Assay Detail
Functional
CHEMBL1018031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A2780 cells after 72 hrs by alamar-blue cell viability assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.24 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514351 | — | — | 2 | 5.80 |
| CHEMBL475796 | — | — | 2 | 5.60 |
| CHEMBL941 | IMATINIB | 4.0 | 2 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514351 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL514351 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL475796 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL475796 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL941 | IMATINIB | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL941 | IMATINIB | IC50 | = | 50118.72 | nM | 4.30 |