Assay Detail
Binding
CHEMBL1018746
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Displacement of [3H]nemonapride from dopamine D2 receptor in rat forebrain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.06 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513174 | — | — | 1 | 7.72 |
| CHEMBL27559 | — | — | 1 | 7.54 |
| CHEMBL255229 | — | — | 1 | 7.14 |
| CHEMBL468056 | — | — | 1 | 7.05 |
| CHEMBL468677 | — | — | 1 | 6.78 |
| CHEMBL482276 | — | — | 1 | 6.72 |
| CHEMBL403550 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513174 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL27559 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL255229 | — | Ki | = | 72.3 | nM | 7.14 |
| CHEMBL468056 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL468677 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL482276 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL403550 | — | Ki | = | 340.0 | nM | 6.47 |