Assay Detail
Binding
CHEMBL1018988
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Displacement of [3H]CGP39653 from NMDA receptor in rat brain membranes
14
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.37 | 6.54 |
| logKi | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.54 |
| CHEMBL467235 | — | — | 2 | 6.14 |
| CHEMBL445241 | — | — | 2 | 5.34 |
| CHEMBL450025 | — | — | 2 | 4.54 |
| CHEMBL448885 | — | — | 2 | 4.28 |
| CHEMBL444718 | — | — | 2 | - |
| CHEMBL467234 | — | — | 2 | - |
| CHEMBL33567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL467235 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL445241 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL450025 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL448885 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL444718 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL467234 | — | logKi | = | 2.09 | — | - |
| CHEMBL33567 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL444718 | — | logKi | = | 2.48 | — | - |
| CHEMBL450025 | — | logKi | = | 1.46 | — | - |
| CHEMBL467234 | — | Ki | = | 124000.0 | nM | - |
| CHEMBL448885 | — | logKi | = | 1.72 | — | - |
| CHEMBL445241 | — | logKi | = | 0.66 | — | - |
| CHEMBL467235 | — | Ki | = | 724435960.07 | nM | - |