Assay Detail
Binding
CHEMBL1020364
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Inhibition of Hsp90 in human SKBR3 cells assessed as Her2 degradation
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of heat shock protein 90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.79 | 7.05 |
| EC50 | 1 | 7.30 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.30 |
| CHEMBL200001 | — | — | 1 | 7.05 |
| CHEMBL365159 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL200001 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL365159 | — | IC50 | = | 300.0 | nM | 6.52 |