Assay Detail
Binding
CHEMBL1020883
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Inhibition of 5HT uptake at rat brain SERT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.73 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316862 | — | — | 1 | 7.89 |
| CHEMBL420644 | — | — | 1 | 6.75 |
| CHEMBL101055 | — | — | 1 | 6.72 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 6.68 |
| CHEMBL101899 | — | — | 1 | 6.50 |
| CHEMBL99653 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316862 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL420644 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL101055 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL637 | VENLAFAXINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL101899 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL99653 | — | IC50 | = | 1440.0 | nM | 5.84 |