Assay Detail
Binding
CHEMBL1022293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat cortex FAAH by [3H]anandamide carbon filtration assay
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.26 | 8.77 |
| Ki | 6 | 8.56 | 10.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367966 | — | — | 1 | 10.55 |
| CHEMBL459920 | — | — | 1 | 8.77 |
| CHEMBL232782 | — | — | 1 | 8.70 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 8.40 |
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL509860 | — | — | 1 | 7.92 |
| CHEMBL467426 | — | — | 1 | 7.89 |
| CHEMBL516782 | — | — | 1 | 7.85 |
| CHEMBL460798 | — | — | 1 | 7.85 |
| CHEMBL461411 | — | — | 1 | 7.82 |
| CHEMBL460127 | — | — | 1 | 7.80 |
| CHEMBL460340 | — | — | 1 | 7.75 |
| CHEMBL460129 | — | — | 1 | 7.72 |
| CHEMBL460128 | — | — | 1 | 7.68 |
| CHEMBL517903 | — | — | 1 | 7.60 |
| CHEMBL512590 | — | — | 1 | 7.54 |
| CHEMBL513789 | — | — | 1 | 7.48 |
| CHEMBL462464 | — | — | 1 | 7.36 |
| CHEMBL511915 | — | — | 1 | 7.32 |
| CHEMBL513142 | — | — | 1 | 7.20 |
| CHEMBL460588 | — | — | 1 | 7.19 |
| CHEMBL459919 | — | — | 1 | 7.15 |
| CHEMBL446296 | — | — | 1 | 7.04 |
| CHEMBL462465 | — | — | 1 | 6.96 |
| CHEMBL518028 | — | — | 1 | 6.68 |
| CHEMBL462466 | — | — | 1 | 6.63 |
| CHEMBL468258 | — | — | 1 | 6.58 |
| CHEMBL518329 | — | — | 1 | 6.57 |
| CHEMBL511421 | — | — | 1 | 5.75 |
| CHEMBL467428 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367966 | — | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL459920 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL232782 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL184238 | URB-597 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL509860 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL467426 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL516782 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL460798 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL461411 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL460127 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL460340 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL460129 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL460128 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL517903 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL512590 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL513789 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL462464 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL511915 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL513142 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL460588 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL459919 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL446296 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL462465 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL518028 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL462466 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL468258 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL518329 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL511421 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL467428 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL461435 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467427 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL460589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462682 | — | IC50 | > | 10000.0 | nM | - |