Compound Detail
CHEMBL460340
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Basic Information
| ChEMBL ID | CHEMBL460340 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IVGKSFUEBSXSAE-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
497.7
MW (Da)
5.37
ALogP
6
HBA
1
HBD
79.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 7.96 | 7.72 | 11.0 | 5 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of human recombinant FAAH expressed in HEK293 cells by [3H]anandamide... | 19072118 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of rat cortex FAAH by [3H]anandamide carbon filtration assay | 19072118 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of FAAH | 21764305 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 19.0 | nM | 7.72 | Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for ... | 19072118 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for ... | 19072118 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 34.0 | nM | 7.47 | Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for ... | 19072118 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19072118 | 10.1021/jm801042a | Fatty-acid amide hydrolase 1 | 5 |
| 19072118 | 10.1021/jm801042a | Unchecked | 3 |
| 21764305 | 10.1016/j.bmcl.2011.06.096 | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine