Assay Detail
Binding
CHEMBL1022745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]endomorphin-2 from mu opioid receptor in Wistar rat brain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New endomorphin analogues containing alicyclic beta-amino acids: influence on bioactive conformation and pharmacological profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.46 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365583 | — | — | 1 | 9.30 |
| CHEMBL363787 | — | — | 1 | 9.14 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.89 |
| CHEMBL450476 | — | — | 1 | 8.82 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.68 |
| CHEMBL508249 | — | — | 1 | 8.20 |
| CHEMBL467089 | — | — | 1 | 8.00 |
| CHEMBL446990 | — | — | 1 | 7.70 |
| CHEMBL506168 | — | — | 1 | 7.08 |
| CHEMBL449748 | — | — | 1 | 6.91 |
| CHEMBL509619 | — | — | 1 | 6.91 |
| CHEMBL455743 | — | — | 1 | 6.84 |
| CHEMBL501894 | — | — | 1 | 6.71 |
| CHEMBL372682 | — | — | 1 | 6.58 |
| CHEMBL447871 | — | — | 1 | 6.48 |
| CHEMBL500623 | — | — | 1 | 6.33 |
| CHEMBL472740 | — | — | 1 | 5.95 |
| CHEMBL192506 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365583 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL363787 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL450476 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL508249 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL467089 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL446990 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL506168 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL449748 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL509619 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL455743 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL501894 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL372682 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL447871 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL500623 | — | Ki | = | 467.0 | nM | 6.33 |
| CHEMBL472740 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL192506 | — | Ki | = | 2049.0 | nM | 5.69 |