Compound Detail
CHEMBL472740
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NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCC[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1
Basic Information
| ChEMBL ID | CHEMBL472740 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCEMFCFLRANOGP-JPQUJUHESA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
638.8
MW (Da)
2.36
ALogP
6
HBA
7
HBD
192.4
PSA (Ų)
0.12
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL270 | Ki | 6.05 | 6.0 | 883.0 | 2 |
| Delta-type opioid receptor CHEMBL269 | Ki | 5.02 | 5.02 | 9617.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 883.0 | nM | 6.05 | Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain | 18572932 |
| Mu-type opioid receptor | Ki | = | 1120.0 | nM | 5.95 | Displacement of [3H]endomorphin-2 from mu opioid receptor in Wistar rat brain | 18572932 |
| Delta-type opioid receptor | Ki | = | 9617.0 | nM | 5.02 | Displacement of [3H]Ile5,6deltorphin-2 from delta opioid receptor in Wistar rat ... | 18572932 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18572932 | 10.1021/jm800223t | Mu-type opioid receptor | 2 |
| 18572932 | 10.1021/jm800223t | Unchecked | 2 |
| 18572932 | 10.1021/jm800223t | Delta-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine