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Assay Detail

CHEMBL1023067

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Hsp90 by surface plasmon resonance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Heat shock protein HSP 90-beta (CHEMBL4303)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and development of heat shock protein 90 inhibitors.
Taldone T, Sun W, Chiosis G.
Bioorg Med Chem (2009) 17 : 2225 -2235
PubMed 19017562 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 6.36 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL360563 1 6.55
CHEMBL178130 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL360563 Kd = 280.0 nM 6.55
CHEMBL178130 Kd = 680.0 nM 6.17