Assay Detail
Functional
CHEMBL1023679
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Antiinflammatory activity in fMLP/cytochalasin B-stimulated human neutrophils assessed as inhibition of superoxide anion generation after 5 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.51 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558556 | — | — | 1 | 6.30 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | 6.16 |
| CHEMBL562672 | — | — | 1 | 5.62 |
| CHEMBL292051 | — | — | 1 | 5.48 |
| CHEMBL558872 | — | — | 1 | 5.26 |
| CHEMBL560020 | — | — | 1 | 4.89 |
| CHEMBL357583 | — | — | 1 | 4.85 |
| CHEMBL558670 | — | — | 1 | - |
| CHEMBL559428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558556 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL562672 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL292051 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL558872 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL560020 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL357583 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL558670 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL559428 | — | IC50 | > | 20000.0 | nM | - |