Assay Detail
Binding
CHEMBL1023735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig ALR1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL4049) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.61 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273910 | MINALRESTAT | 2.0 | 1 | 7.40 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 5.66 |
| CHEMBL449129 | — | — | 1 | 4.95 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273910 | MINALRESTAT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL449129 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL50 | QUERCETIN | IC50 | = | 38400.0 | nM | 4.42 |