Assay Detail
Functional
CHEMBL1023996
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Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiopyrano[2,3-e]indol-2-ones: angelicin heteroanalogues with potent photoantiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.68 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196028 | — | — | 1 | 6.30 |
| CHEMBL53569 | ANGELICIN | — | 1 | 6.05 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 5.92 |
| CHEMBL371273 | — | — | 1 | 5.60 |
| CHEMBL197313 | — | — | 1 | 5.40 |
| CHEMBL193565 | — | — | 1 | 5.38 |
| CHEMBL460825 | — | — | 1 | 5.14 |
| CHEMBL193926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196028 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL371273 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL197313 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL193565 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL460825 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL193926 | — | IC50 | > | 10000.0 | nM | - |