Assay Detail
Functional
CHEMBL1024869
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Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492437 | — | — | 1 | 9.00 |
| CHEMBL493266 | — | — | 1 | 9.00 |
| CHEMBL555476 | — | — | 1 | 8.70 |
| CHEMBL521523 | — | — | 1 | 8.60 |
| CHEMBL493265 | — | — | 1 | 8.60 |
| CHEMBL493465 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492437 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL493266 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL555476 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL521523 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL493265 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL493465 | — | Kd | = | 7.943 | nM | 8.10 |