Assay Detail
Functional
CHEMBL1025650
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Agonist activity at adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells assessed as stimulation of cAMP accumulation by radioimmunoassay in presence of 1 uM DPCPX
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mesocricetus auratus |
| Cell Type | DDT1 MF2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.23 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524037 | — | — | 1 | 8.22 |
| CHEMBL1160723 | LEVISOPRENALINE | 2.0 | 1 | 7.70 |
| CHEMBL462273 | — | — | 1 | 7.50 |
| CHEMBL493489 | — | — | 1 | 6.75 |
| CHEMBL462274 | — | — | 1 | 5.96 |
| CHEMBL517259 | — | — | 1 | - |
| CHEMBL460361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524037 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1160723 | LEVISOPRENALINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL462273 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL493489 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL462274 | — | EC50 | = | 1087.0 | nM | 5.96 |
| CHEMBL517259 | — | EC50 | - | — | - | |
| CHEMBL460361 | — | EC50 | - | — | - |