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Compound Detail

CHEMBL524037

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O=CNc1cc(C(O)CNCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1O

Basic Information

ChEMBL ID CHEMBL524037
Phase Preclinical
Structure Type MOL
InChI Key RYVVFUHRFAJPCC-NDIYSDBASA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

545.6
MW (Da)
0.01
ALogP
13
HBA
8
HBD
207.1
PSA (Ų)
0.07
QED
3
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H35N7O7
MW 545.60
Aromatic Rings 3
Heavy Atoms 39
NP-Likeness 0.45

Activity Summary

Ki 2 meas. best 6.51
EC50 1 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL5943
EC50 8.22 8.22 6.0 1
Beta-2 adrenergic receptor
CHEMBL5943
Ki 6.51 6.51 311.0 1
Unchecked
CHEMBL612545
Ki 6.36 6.36 436.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18783211 10.1021/jm800613s Beta-2 adrenergic receptor 6
18783211 10.1021/jm800613s Unchecked 2

Data from ChEMBL 36 via Core Engine