Assay Detail
Binding
CHEMBL1027052
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Displacement of [3H]DADLE from delta opioid receptor in rat cerebellum membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.53 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552308 | — | — | 1 | 9.85 |
| CHEMBL559518 | — | — | 1 | 9.72 |
| CHEMBL564538 | — | — | 1 | 9.72 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.54 |
| CHEMBL327745 | — | — | 1 | 8.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552308 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL559518 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL564538 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL327745 | — | Ki | = | 1.44 | nM | 8.84 |