Assay Detail
Functional
CHEMBL1027319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.80 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460005 | — | — | 1 | 8.83 |
| CHEMBL460020 | — | — | 1 | 8.35 |
| CHEMBL461055 | — | — | 1 | 8.31 |
| CHEMBL301982 | CELASTROL | — | 1 | 7.42 |
| CHEMBL465226 | GEDUNIN | — | 1 | 7.41 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 7.40 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.37 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460005 | — | EC50 | = | 1.49 | nM | 8.83 |
| CHEMBL460020 | — | EC50 | = | 4.482 | nM | 8.35 |
| CHEMBL461055 | — | EC50 | = | 4.85 | nM | 8.31 |
| CHEMBL301982 | CELASTROL | EC50 | = | 37.64 | nM | 7.42 |
| CHEMBL465226 | GEDUNIN | EC50 | = | 38.95 | nM | 7.41 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | EC50 | = | 39.87 | nM | 7.40 |
| CHEMBL278315 | GELDANAMYCIN | EC50 | = | 42.69 | nM | 7.37 |
| CHEMBL36506 | NOVOBIOCIN | EC50 | = | 48.39 | nM | 7.32 |