Assay Detail
Functional
CHEMBL1027499
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Cytotoxicity against human HL60 cells after 48 hrs by trypan blue exclusion assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reaction of irofulven with zinc and acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509170 | ILLUDIN | — | 1 | 8.52 |
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.14 |
| CHEMBL506735 | INDENE | — | 1 | - |
| CHEMBL507342 | — | — | 1 | - |
| CHEMBL466576 | — | — | 1 | - |
| CHEMBL468448 | — | — | 1 | - |
| CHEMBL455253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509170 | ILLUDIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL118218 | IROFULVEN | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL506735 | INDENE | IC50 | = | 140000.0 | nM | - |
| CHEMBL507342 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL466576 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL468448 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL455253 | — | IC50 | = | 110000.0 | nM | - |