Assay Detail
Binding
CHEMBL1028080
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Inhibition of EGFR
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475768 | — | — | 1 | 9.00 |
| CHEMBL475594 | — | — | 1 | 8.70 |
| CHEMBL473428 | — | — | 1 | 8.52 |
| CHEMBL473429 | — | — | 1 | 8.52 |
| CHEMBL474431 | — | — | 1 | 8.52 |
| CHEMBL475769 | — | — | 1 | 8.40 |
| CHEMBL473437 | — | — | 1 | 8.40 |
| CHEMBL475761 | GW784684X | — | 1 | 8.30 |
| CHEMBL473438 | — | — | 1 | 8.22 |
| CHEMBL475446 | — | — | 1 | 8.15 |
| CHEMBL473427 | — | — | 1 | 8.10 |
| CHEMBL506414 | GW684626B | — | 1 | 8.05 |
| CHEMBL479800 | — | — | 1 | 8.00 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | 4.0 | 1 | 7.96 |
| CHEMBL480349 | — | — | 1 | 7.92 |
| CHEMBL514938 | GSK-969786A | — | 1 | 7.82 |
| CHEMBL519757 | — | — | 1 | 7.27 |
| CHEMBL473436 | — | — | 1 | 7.17 |
| CHEMBL475767 | — | — | 1 | 7.17 |
| CHEMBL481324 | — | — | 1 | 7.02 |
| CHEMBL475600 | — | — | 1 | 6.94 |
| CHEMBL480348 | — | — | 1 | 6.92 |
| CHEMBL481331 | — | — | 1 | 6.86 |
| CHEMBL475599 | GSK-300014A | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475768 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL475594 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL473428 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL473429 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL474431 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL475769 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL473437 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL475761 | GW784684X | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL473438 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL475446 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL473427 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL506414 | GW684626B | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL479800 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL480349 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL514938 | GSK-969786A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL519757 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL473436 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL475767 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL481324 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL475600 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL480348 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL481331 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL475599 | GSK-300014A | IC50 | = | 304.0 | nM | 6.52 |