Compound Detail
CHEMBL475761
GW784684X Enter ChEMBL ID:
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CN1CCN(Cc2ccc(-c3cc4ncnc(Nc5ccc(OCc6cccc(F)c6)c(Cl)c5)c4s3)o2)CC1
Basic Information
| ChEMBL ID | CHEMBL475761 |
| Name | GW784684X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MFBTVPWNHQVGPL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
564.1
MW (Da)
6.81
ALogP
8
HBA
1
HBD
66.7
PSA (Ų)
0.22
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Receptor tyrosine-protein kinase erbB-2 CHEMBL1824 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 5.0 | nM | 8.3 | Inhibition of EGFR | 19111461 |
| Receptor tyrosine-protein kinase erbB-2 | IC50 | = | 250.0 | nM | 6.6 | Inhibition of ErbB2 | 19111461 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 28 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 20 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 16 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 16 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 12 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 8 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 8 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 8 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 8 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 8 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 8 |
| - | 10.6019/CHEMBL1961873 | Rhodopsin kinase GRK7 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK alpha | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK beta | 4 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 4 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-4 | 4 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase beta-1 | 4 |
| - | 10.6019/CHEMBL1961873 | RAC-beta serine/threonine-protein kinase | 4 |
| - | 10.6019/CHEMBL1961873 | RAC-alpha serine/threonine-protein kinase | 4 |
| - | 10.6019/CHEMBL1961873 | RAF proto-oncogene serine/threonine-protein kinase | 4 |
Data from ChEMBL 36 via Core Engine