Assay Detail
Binding
CHEMBL1028978
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Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.04 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495327 | — | — | 1 | 5.47 |
| CHEMBL494509 | — | — | 1 | 5.36 |
| CHEMBL494511 | — | — | 1 | 5.31 |
| CHEMBL494308 | — | — | 1 | 5.27 |
| CHEMBL492664 | — | — | 1 | 4.96 |
| CHEMBL492883 | — | — | 1 | 4.89 |
| CHEMBL494309 | — | — | 1 | 4.89 |
| CHEMBL494510 | — | — | 1 | 4.19 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | - |
| CHEMBL524005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495327 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL494509 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL494511 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL494308 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL492664 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL492883 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL494309 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL494510 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL301265 | PRAMIPEXOLE | Ki | > | 100000.0 | nM | - |
| CHEMBL524005 | — | Ki | > | 50000.0 | nM | - |