Assay Detail
ADMET
CHEMBL1029448
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Inhibition of human CYP3A4 assessed as biotransformation of 7-benzyloxyquinoline
15
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.21 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 7.62 |
| CHEMBL564408 | — | — | 2 | 6.80 |
| CHEMBL558873 | — | — | 2 | 6.60 |
| CHEMBL98745 | NARCICLASINE | — | 2 | 6.20 |
| CHEMBL251077 | — | — | 2 | 5.12 |
| CHEMBL465295 | — | — | 2 | 5.00 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | - |
| CHEMBL400092 | LYCORINE | — | 1 | - |
| CHEMBL419335 | PANCRATISTATIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL564408 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL564408 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL558873 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL558873 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL98745 | NARCICLASINE | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL98745 | NARCICLASINE | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL251077 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL251077 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL465295 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL465295 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL659 | GALANTAMINE | Ki | - | — | - | |
| CHEMBL400092 | LYCORINE | Ki | - | — | - | |
| CHEMBL419335 | PANCRATISTATIN | Ki | - | — | - |