Assay Detail
Binding
CHEMBL1029735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.96 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL35 | FUROSEMIDE | 4.0 | 1 | 6.61 |
| CHEMBL1055 | CHLORTHALIDONE | 4.0 | 1 | 5.87 |
| CHEMBL406 | INDAPAMIDE | 4.0 | 1 | 5.79 |
| CHEMBL1054 | TRICHLORMETHIAZIDE | 4.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL35 | FUROSEMIDE | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL1055 | CHLORTHALIDONE | Ki | = | 1347.0 | nM | 5.87 |
| CHEMBL406 | INDAPAMIDE | Ki | = | 1606.0 | nM | 5.79 |
| CHEMBL1054 | TRICHLORMETHIAZIDE | Ki | = | 2459.0 | nM | 5.61 |