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Assay Detail

CHEMBL1032965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of ionomycin-stimulated LTB4 production in human whole blood treated 15 mins prior to ionomycin challenge measured after 30 mins of stimulation by enzyme-linked immunosorbent assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Blood
Confidence 1 — Organism
Curated By Autocuration

Target

Blood (CHEMBL613416)
Type TISSUE
Organism Homo sapiens

Publication

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ.
J Med Chem (2009) 52 : 4694 -4715
PubMed 19618939 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.55 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL563693 1 7.43
CHEMBL570775 1 6.88
CHEMBL561639 1 5.34
CHEMBL165 RESVERATROL 3.0 1 -
CHEMBL111234 DIHYDRORESVERATROL 1 -
CHEMBL264669 1 -
CHEMBL194009 1 -
CHEMBL563196 1 -
CHEMBL483790 1 -
CHEMBL538940 1 -
CHEMBL539640 1 -
CHEMBL549343 1 -
CHEMBL404923 1 -
CHEMBL555013 1 -
CHEMBL555457 1 -
CHEMBL563692 1 -
CHEMBL562164 1 -
CHEMBL558285 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL563693 IC50 = 37.3 nM 7.43
CHEMBL570775 IC50 = 131.0 nM 6.88
CHEMBL561639 IC50 = 4580.0 nM 5.34
CHEMBL165 RESVERATROL IC50 - -
CHEMBL111234 DIHYDRORESVERATROL IC50 - -
CHEMBL264669 IC50 - -
CHEMBL194009 IC50 - -
CHEMBL563196 IC50 - -
CHEMBL483790 IC50 - -
CHEMBL538940 IC50 - -
CHEMBL539640 IC50 - -
CHEMBL549343 IC50 - -
CHEMBL404923 IC50 - -
CHEMBL555013 IC50 - -
CHEMBL555457 IC50 - -
CHEMBL563692 IC50 - -
CHEMBL562164 IC50 - -
CHEMBL558285 IC50 - -