Assay Detail
Binding
CHEMBL1033535
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Inhibition of equine serum BuChE by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.16 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550075 | — | — | 1 | 6.22 |
| CHEMBL559266 | — | — | 1 | 5.57 |
| CHEMBL395926 | — | — | 1 | 5.55 |
| CHEMBL559502 | — | — | 1 | 5.40 |
| CHEMBL549666 | — | — | 1 | 5.32 |
| CHEMBL551226 | — | — | 1 | 5.30 |
| CHEMBL556249 | — | — | 1 | 5.29 |
| CHEMBL563713 | — | — | 1 | 5.21 |
| CHEMBL541019 | — | — | 1 | 5.17 |
| CHEMBL550076 | — | — | 1 | 5.09 |
| CHEMBL549935 | — | — | 1 | 5.01 |
| CHEMBL559822 | — | — | 1 | 4.93 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.84 |
| CHEMBL549936 | — | — | 1 | 4.27 |
| CHEMBL551430 | — | — | 1 | 4.16 |
| CHEMBL246681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550075 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL559266 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL395926 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL559502 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL549666 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL551226 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL556249 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL563713 | — | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL541019 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL550076 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL549935 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL559822 | — | IC50 | = | 11690.0 | nM | 4.93 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL549936 | — | IC50 | = | 53250.0 | nM | 4.27 |
| CHEMBL551430 | — | IC50 | = | 68730.0 | nM | 4.16 |
| CHEMBL246681 | — | IC50 | > | 100000.0 | nM | - |