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Evidence Snapshot

Cholinesterase

CHEMBL5763 SINGLE PROTEIN Equus caballus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:27Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5763
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cholinesterase as ChEMBL target CHEMBL5763, mapped to UniProt P81908. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cholinesterase
SINGLE PROTEIN · Equus caballus
As of 2026-09-13
ChEMBL target ID
CHEMBL5763
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P81908
Cholinesterase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cholinesterase matters

As of 2026-09-13

Cholinesterase is reviewed as Cholinesterase (UniProt P81908); the current evidence base includes 34 approved drugs, 7437 compounds, and 857 assays, with lead potency reaching pChEMBL 10.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 34 approved drugs, 7437 compounds, and 857 assays for this target. The dominant activity type is IC50. CHEMBL5201089 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL5201089 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
34 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cholinesterase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P81908, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

7437
Total Compounds
857
Total Assays
34
Approved Drugs
IC50: 6380.0, KI: 433.0, KD: 8.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5201089
 10.7 IC50 —
No preferred name
CHEMBL2158116
 10.3 IC50 —
No preferred name
CHEMBL5592238
 10.3 IC50 —
No preferred name
CHEMBL5595714
 10.2 IC50 —
No preferred name
CHEMBL5584158
 10.1 IC50 —

Approved Drugs

Structure Compound First Approval
CANNABIDIOL
CHEMBL190461
 2018
NEOSTIGMINE
CHEMBL278020
 2013
RIVASTIGMINE
CHEMBL636
 1998
RIVASTIGMINE TARTRATE
CHEMBL1201092
 1998
DONEPEZIL
CHEMBL502
 1996
TACRINE
CHEMBL95
 1993
TACRINE HYDROCHLORIDE
CHEMBL1677
 1993
SIMVASTATIN
CHEMBL1064
 1991
ETHOPROPAZINE
CHEMBL1206
 1982
DIAZEPAM
CHEMBL12
 1963
CHLORDIAZEPOXIDE HYDROCHLORIDE
CHEMBL1200703
 1960
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:27Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5763