Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1033993

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Herpes simplex virus 2
ChEMBL ↗
47
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 2
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 2 (CHEMBL370) ↗
Type ORGANISM
Organism Human alphaherpesvirus 2

Publication

Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Prado-Prado FJ, Martinez de la Vega O, Uriarte E, Ubeira FM, Chou KC, González-Díaz H.
Bioorg Med Chem (2009) 17 : 569 -575
PubMed 19112024 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 8.83 10.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL346387 — — 1 10.77
CHEMBL484 ADEFOVIR 3.0 1 10.62
CHEMBL504793 — — 2 10.48
CHEMBL301240 — — 1 10.28
CHEMBL298845 — — 1 10.04
CHEMBL358153 — — 1 9.92
CHEMBL356437 — — 1 9.92
CHEMBL59520 — — 1 9.58
CHEMBL57548 — — 1 9.54
CHEMBL146197 — — 1 9.18
CHEMBL147814 — — 1 9.15
CHEMBL148716 — — 1 9.11
CHEMBL56641 — — 1 9.00
CHEMBL57384 — — 1 9.00
CHEMBL299704 — — 1 8.96
CHEMBL356695 — — 1 8.92
CHEMBL148304 — — 1 8.92
CHEMBL150124 — — 1 8.92
CHEMBL356135 — — 1 8.92
CHEMBL149197 — — 1 8.92
CHEMBL150057 — — 1 8.92
CHEMBL146182 — — 1 8.92
CHEMBL149664 — — 1 8.92
CHEMBL146699 — — 1 8.92
CHEMBL149116 — — 1 8.92
CHEMBL342983 — — 1 8.92
CHEMBL57452 — — 1 8.92
CHEMBL149174 — — 1 8.92
CHEMBL58026 — — 1 8.86
CHEMBL59144 — — 1 8.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL346387 — IC50 = 0.017 nM 10.77
CHEMBL484 ADEFOVIR IC50 = 0.024 nM 10.62
CHEMBL504793 — IC50 = 0.033 nM 10.48
CHEMBL504793 — IC50 = 0.03623 nM 10.44
CHEMBL301240 — IC50 = 0.05263 nM 10.28
CHEMBL298845 — IC50 = 0.09091 nM 10.04
CHEMBL358153 — IC50 = 0.12 nM 9.92
CHEMBL356437 — IC50 = 0.12 nM 9.92
CHEMBL59520 — IC50 = 0.2632 nM 9.58
CHEMBL57548 — IC50 = 0.2857 nM 9.54
CHEMBL146197 — IC50 = 0.66 nM 9.18
CHEMBL147814 — IC50 = 0.7 nM 9.15
CHEMBL148716 — IC50 = 0.77 nM 9.11
CHEMBL57384 — IC50 = 0.9926 nM 9.00
CHEMBL56641 — IC50 = 0.9926 nM 9.00
CHEMBL299704 — IC50 = 1.099 nM 8.96
CHEMBL356135 — IC50 = 1.2 nM 8.92
CHEMBL146699 — IC50 = 1.2 nM 8.92
CHEMBL149116 — IC50 = 1.2 nM 8.92
CHEMBL342983 — IC50 = 1.2 nM 8.92
CHEMBL57452 — IC50 = 1.201 nM 8.92
CHEMBL149174 — IC50 = 1.2 nM 8.92
CHEMBL148304 — IC50 = 1.2 nM 8.92
CHEMBL149197 — IC50 = 1.2 nM 8.92
CHEMBL146182 — IC50 = 1.2 nM 8.92
CHEMBL149664 — IC50 = 1.2 nM 8.92
CHEMBL356695 — IC50 = 1.2 nM 8.92
CHEMBL150057 — IC50 = 1.2 nM 8.92
CHEMBL150124 — IC50 = 1.2 nM 8.92
CHEMBL58026 — IC50 = 1.37 nM 8.86
CHEMBL59144 — IC50 = 1.423 nM 8.85
CHEMBL58370 — IC50 = 1.606 nM 8.79
CHEMBL56723 — IC50 = 2.597 nM 8.59
CHEMBL31634 BRIVUDINE IC50 = 76.0 nM 7.12
CHEMBL413063 — IC50 = 2200.0 nM 5.66
CHEMBL186389 — IC50 = 3300.0 nM 5.48
CHEMBL364765 — IC50 = 8000.0 nM 5.10
CHEMBL344107 — IC50 = 9060.0 nM 5.04
CHEMBL421982 — IC50 = 420000.0 nM -
CHEMBL347817 — IC50 = 380000.0 nM -
CHEMBL189399 — IC50 = 200000.0 nM -
CHEMBL265948 FILOCICLOVIR IC50 = 380000.0 nM -
CHEMBL151794 — IC50 = 448000.0 nM -
CHEMBL146350 — IC50 = 291000.0 nM -
CHEMBL157102 — IC50 = 404000.0 nM -
CHEMBL152335 — IC50 = 381000.0 nM -
CHEMBL513554 — IC50 = 361000.0 nM -