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Assay Detail

CHEMBL1034018

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Functional
Antiviral activity against Varicella zoster virus
ChEMBL ↗
49
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 3 (CHEMBL613132) ↗
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Prado-Prado FJ, Martinez de la Vega O, Uriarte E, Ubeira FM, Chou KC, González-Díaz H.
Bioorg Med Chem (2009) 17 : 569 -575
PubMed 19112024 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 8.14 10.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL342983 — — 1 10.74
CHEMBL484 ADEFOVIR 3.0 1 10.46
CHEMBL57548 — — 1 10.27
CHEMBL356695 — — 1 10.08
CHEMBL146699 — — 1 9.96
CHEMBL56641 — — 1 9.91
CHEMBL57384 — — 1 9.91
CHEMBL299704 — — 1 9.86
CHEMBL148304 — — 1 9.82
CHEMBL149664 — — 1 9.82
CHEMBL146182 — — 1 9.82
CHEMBL149197 — — 1 9.82
CHEMBL150124 — — 1 9.82
CHEMBL149116 — — 1 9.82
CHEMBL57452 — — 1 9.82
CHEMBL147814 — — 1 9.82
CHEMBL148716 — — 1 9.82
CHEMBL146197 — — 1 9.82
CHEMBL150057 — — 1 9.82
CHEMBL59520 — — 1 9.78
CHEMBL301240 — — 1 9.78
CHEMBL58026 — — 1 9.77
CHEMBL59144 — — 1 9.75
CHEMBL58370 — — 1 9.70
CHEMBL56723 — — 1 9.49
CHEMBL356135 — — 1 8.92
CHEMBL504793 — — 2 6.65
CHEMBL376591 — — 1 6.21
CHEMBL464972 — — 1 6.21
CHEMBL473690 — — 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL342983 — IC50 = 0.018 nM 10.74
CHEMBL484 ADEFOVIR IC50 = 0.035 nM 10.46
CHEMBL57548 — IC50 = 0.05357 nM 10.27
CHEMBL356695 — IC50 = 0.084 nM 10.08
CHEMBL146699 — IC50 = 0.11 nM 9.96
CHEMBL56641 — IC50 = 0.1241 nM 9.91
CHEMBL57384 — IC50 = 0.1241 nM 9.91
CHEMBL299704 — IC50 = 0.1374 nM 9.86
CHEMBL150057 — IC50 = 0.15 nM 9.82
CHEMBL149664 — IC50 = 0.15 nM 9.82
CHEMBL146182 — IC50 = 0.15 nM 9.82
CHEMBL149197 — IC50 = 0.15 nM 9.82
CHEMBL148304 — IC50 = 0.15 nM 9.82
CHEMBL150124 — IC50 = 0.15 nM 9.82
CHEMBL149116 — IC50 = 0.15 nM 9.82
CHEMBL57452 — IC50 = 0.1501 nM 9.82
CHEMBL147814 — IC50 = 0.15 nM 9.82
CHEMBL148716 — IC50 = 0.15 nM 9.82
CHEMBL146197 — IC50 = 0.15 nM 9.82
CHEMBL59520 — IC50 = 0.1645 nM 9.78
CHEMBL301240 — IC50 = 0.1645 nM 9.78
CHEMBL58026 — IC50 = 0.1712 nM 9.77
CHEMBL59144 — IC50 = 0.1779 nM 9.75
CHEMBL58370 — IC50 = 0.2008 nM 9.70
CHEMBL56723 — IC50 = 0.3247 nM 9.49
CHEMBL356135 — IC50 = 1.2 nM 8.92
CHEMBL504793 — IC50 = 226.0 nM 6.65
CHEMBL376591 — IC50 = 620.0 nM 6.21
CHEMBL464972 — IC50 = 620.0 nM 6.21
CHEMBL473690 — IC50 = 680.0 nM 6.17
CHEMBL508592 — IC50 = 1200.0 nM 5.92
CHEMBL513554 — IC50 = 3000.0 nM 5.52
CHEMBL186389 — IC50 = 5000.0 nM 5.30
CHEMBL224595 — IC50 = 14000.0 nM 4.85
CHEMBL504176 — IC50 = 14700.0 nM 4.83
CHEMBL31634 BRIVUDINE IC50 = 29000.0 nM 4.54
CHEMBL152335 — IC50 = 39000.0 nM 4.41
CHEMBL189399 — IC50 = 40000.0 nM 4.40
CHEMBL390155 — IC50 = 79600.0 nM 4.10
CHEMBL223933 — IC50 = 79600.0 nM 4.10
CHEMBL375155 — IC50 = 83400.0 nM 4.08
CHEMBL346387 — IC50 = 0.00017 nM -
CHEMBL504793 — IC50 = 0.0095 nM -
CHEMBL157102 — IC50 = 404000.0 nM -
CHEMBL151794 — IC50 = 448000.0 nM -
CHEMBL265948 FILOCICLOVIR IC50 = 380000.0 nM -
CHEMBL421982 — IC50 = 420000.0 nM -
CHEMBL426177 — IC50 = 442000.0 nM -
CHEMBL347817 — IC50 = 380000.0 nM -