Assay Detail
Functional
CHEMBL1034082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.56 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.80 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 6.50 |
| CHEMBL472269 | — | — | 1 | 6.09 |
| CHEMBL420843 | — | — | 1 | 5.68 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.44 |
| CHEMBL252036 | GS-9148 | -1.0 | 1 | 4.92 |
| CHEMBL525256 | — | — | 1 | 4.80 |
| CHEMBL428083 | — | — | 1 | 4.28 |
| CHEMBL471431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL472269 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL420843 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL252036 | GS-9148 | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL525256 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL428083 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL471431 | — | EC50 | = | 244000.0 | nM | - |